There is no specific treatment for the mutation itself. Clotting Disorders. This gene is responsible for aiding in normal blood clotting. Is an uncertain result possible, and what would that mean? Symptoms of deep vein thrombosis in your arm or leg include: Symptoms of a pulmonary embolism (located in your lung) include: It is a genetic mutation in your Factor II gene that makes it create too much prothrombin (coagulation factor II), and you end up with a higher risk of developing blood clots than someone with a normal prothrombin gene. Zoppi, Lois. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). But you will have to be careful about how much fat and salt you are eating, as well, if you were told to limit them in your diet. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Can the results of the test affect my ability to obtain health insurance? 0000022790 00000 n Fatty fish: Aim for two servings of fatty fish each week, such as salmon, tuna and sardines. The amount of weight that you can lose, however, depends on many things, including your size, gender, and activity level. About 1 out of 10,000 people will develop a DVT or PE each year. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Being able to have a day when you can enjoy any food you want is a big plus, too. But you will have to be very organized and motivated to stay on track. However, the disorder raises your risk compared to people without the disorder. Blood clots in the deep veins in your legs (called deep vein thrombosis or DVT) or in your lungs (called pulmonary embolus or PE) can be dangerous. Start With This 7-Day Meal Plan, 10 Effortless Ways to Finally Cut Down on Salt. This means that for children with factor V Leiden, one out of 5,000-10,000 will get a blood clot. You have 1 Factor V Leiden gene from one parent and 1 normal Factor V gene from your other parent. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Tips on transitioning to a whole food fertility diet. There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. Counseling prior to taking birth control pills or before becoming pregnant. Get useful, helpful and relevant health + wellness information. Large amounts of garlic, ginger, glucosamine (an amino sugar), ginseng, and ginkgo should be avoided while on anticoagulant medications as they may increase the risk of bleeding. Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. This happens because your body makes more of the Factor II (prothrombin) protein than you need for normal clot formation. Heart-healthy foods help reduce inflammation and may help you get to a healthy weight, both of which are necessary for healthy blood, per Johns Hopkins Medicine. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. Tenderness or pain in your leg or arm, which you may only feel when standing or moving around. What are my risks? 2. Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. There is no specific "diet" for people with factor V Leiden, but there are foods that can help keep your blood and body healthy, which may reduce your risk of developing a blood clot. Build physical activity into your daily life. If you have factor V Leiden, you may have many questions. Check with your provider. Your F5 gene controls the production of a protein called factor V, which helps your blood clot when needed (such as after an injury). Venous thromboembolism. Women have a greater chance of developing a blood clot during pregnancy. There are many programs, websites and tools that can help you quit. THE DOCTORS COULD NOT FIGURE OUT WHERE MY BLOOD CLOTS WERE COMING FROM SINCE I DID NOT HAVE ANY DVT'S. <]>> https://www.uptodate.com/contents/search. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. If you have factor V Leiden, there are other ways you can help reduce your risk of developing a blood clot beyond your diet. Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Farshchi, H. American Journal of Clinical Nutrition, January 2005. But the plan would have to be modified to make it appropriate if you have these or other conditions. All rights reserved. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Take frequent breaks during long car rides to get out and stretch your legs. If you cant walk around, flex your ankles and point your toes up and down. Most people with this disorder never develop a blood clot. 78 0 obj<>stream Adults need approximately 1 microgram/kg body weight of vitamin K a day. We do not endorse non-Cleveland Clinic products or services. Fewer than 1 in 100 people of Asian descent. Symptoms of a blood clot depend on what part of your body is affected. Try to build up to 150 minutes of moderate-intensity. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. Vitamin K is found in the following foods: Liver meat Broccoli Brussels sprouts Cabbage Cheese Collard greens Kale Lentils Flaxseed Lettuce Spinach Soybean oil Turnip greens Camomile Green tea. Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. It is not a disease. Nothing beats getting vitamins and minerals from food. Talk to your provider to see if you should be taking a blood thinner. News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Factor V is a protein that is needed for blood to clot properly. There are 2 copies for Factor V gene, which are passed down from our parents. However, your doctor might suggest that you take extra precautions to prevent blood clots if you have the factor V Leiden mutation and are going to have surgery. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. 0000006483 00000 n But because there are many risk factors associated with the development of those pregnancy complications, theres still debate and uncertainty as to how much the factor V Leiden mutation is a cause or just another contributing factor to those pregnancy complications. Factor V is a protein that is needed for blood to clot properly. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Exercise: Required. It may ease your mind to know that most people with this disorder never have a blood clot. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Inherited thrombophilias in pregnancy. (On the contrary, these are all heart-healthy foods.). AHA: "Shaking the Salt Habit to Lower High Blood Pressure", Harvard T. H. Chan School of Public Health: "Vitamin K", AHA: "Understanding Your Risk for Excessive Blood Clotting", Using hormone therapy, including birth control pills, Immobility, either from lack of exercise, disability or sitting for long periods of time. However, there are things that you can do to reduce your chances of developing a dangerous blood clot. At this time, we cant treat or change our genes. 3. https://www.uptodate.com/contents/search. Factor V Leiden is a blood clotting disorder. With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. When you are ready, talk with your health care provider for advice and help to stop smoking. If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. . Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . 0000007474 00000 n .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. Because its an inherited condition, you cant prevent the prothrombin gene mutation. Your doctor may suspect factor V Leiden if you've had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. Mayo Clinic does not endorse companies or products. Factor V Leiden doesnt affect life expectancy in most people. In heterozygous carriers of this mutation, the risk of developing a deep vein thrombosis or pulmonary embolism is about two to three in 1,000. This can be a life-threatening situation. Up to 1 in 50 people who are Black, Hispanic or Native American. These medications (called anticoagulants) help to prevent clotting. About 1 of every 250 Black people in America has the prothrombin gene mutation. Rather, it's key to keep your intake of the nutrient consistent. A blood test (called a screening test) can show if you have Activated Protein C resistance. .wpcdt-timer-24806 {background-color: #aaaaaa;}.wpcdt-timer-24806 .wpcdt-title, .wpcdt-timer-24806 .wpcdt-desc, .wpcdt-timer-24806 .wpcdt-desc p{color: #b81d32;}.wpcdt-timer-24806 .wpcdt-clock-circle h4, This disorder affects factor V, as opposed to other proteins in your blood. Vitamin K is necessary for making the proteins that aid in blood clotting, according to the Harvard T.H. Accessed June 4, 2018. But if you have a blood clotting disorder, your blood forms clots more easily than normal. Instead, they have an different form called Factor V Leiden. Factor V Leiden. How does prothrombin gene mutation affect my body? The prevalence of factor V Leiden varies by ethnicity. Did I get the mutation from both parents or just one? Changing your diet is a good way to reduce your chance of clotting, especially when you take blood thinners. U.S. National Institutes of Health, National Human Genome Research Institute. Vitamin K is found in the following foods: Flaxseed may inhibit the proper absorption of anticoagulants. Do I need to take medication to prevent additional blood clots? 0000003332 00000 n If youre taking warfarin, youll need routine blood testing (prothrombin time test) to check how well your medication is working. Factors that increase this risk include: Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). 0000237253 00000 n In: Williams Hematology. This change causes it to resist other proteins that stop excessive clotting. The weight loss and increased activity that The 5-Factor Diet promises are key to the prevention and treatment of many conditions, including heart disease, high blood pressure, and diabetes. NBCA provides the information and materials on this site for general information purposes only. If you get the mutation from both of your parents, you are homozygous (you have two abnormal copies of the Factor II gene). The factor V Leiden mutation changes this proteins structure. 0000006951 00000 n In: Kaushansky K, Prchal JT, Burns LJ, Lichtman MA, Levi M, Linch DC, eds. (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). Laboratory testing (blood tests) diagnose this disorder. One of these factors is Factor V (FV) Leiden (rs6025), which is a missense variant caused by a single nucleotide polymorphism (SNP) in the F5 gene. Hereditary thrombophilia. This gene carries instructions that tell your body how to properly create the factor V protein. ", cdc.gov: "How much physical activity do adults need?". Keeping your intake of vitamin K at a even level will help maintain your blood thinners (especially warfarin) levels. This disorder may raise your risk of a miscarriage or other complications. Healthy fat (from fish such as salmon, tuna, mackerel, sardines, rainbow trout, or peanut oil, olive oil, canola oil, sunflower oil, Sugar-free drinks (water, sugar-free soda, coffee, tea, or an unsweetened energy drink). Though exercise is an important part of the 5-Factor Diet, the recommended amount falls a bit short of the 150 minutes a week of aerobic activity coupled with strength training that most experts recommend. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. %PDF-1.5 % Serious illness, casts and surgery can increase your chances of developingblood clots. If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. When you are ready, talk with your health care provider for advice and help to lose weight. https://www.uptodate.com/contents/search. In the spring of 2010, I was working and felt that it was a little difficult to bend my right knee / walk - I felt very little swelling / heat so I thought little of it, especially in light of a prior history of having knee problems in that same leg. Information on diseasemaps.org is reported by users and is not medical advice. Results from the PT test are expressed as a ratio called the international normalized ratio (INR). The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. Factor V Leiden (pronounced FAK-ter five LYE-den) is a blood clotting disorder that raises your risk of abnormal blood clots. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. 0 Although the prothrombin gene mutation is the second most common inherited predisposition to a deep vein thrombosis or pulmonary embolism, it is the weakest of all inherited clotting disorders in terms of risk of causing abnormal blood clots. Study Results Demonstrate VTE Treatment Satisfaction Among Patients, Managing Anticoagulants Before, During, and After Medical Procedures, Helping Women Make Choices About Contraception Following DVT Blood Clots, Panel Discussion: Blood Clots & Womens Health, Frequently Asked Questions: COVID-19 and Blood Clotting, Stop the Clot, Spread the Word Hospitalization, Toolkit for Knee and Hip Replacement Patients, Health Disparities and the VTE Mississippi Initiative, Atrial Fibrillation (AFib) and Clot-Provoked Stroke, Questions to Ask Your Doctor After Having a Blood Clot, NBCA Atrial Fibrillation Awareness Survey, Impact of Blood Clots in the Black Community Research Opportunities, NBCA Sports & Wellness Institute: Team Stop the Clot, Council of Emerging Researchers in Thrombosis (CERT), Medical & Scientific Advisory Board (MASAB), not enough clotting power leads to bleeding problems, too much clotting power can lead to the formation of dangerous blood clots. A variety of herbs and vitamins may interact with anticoagulants. If youve had a deep vein thrombosis or pulmonary embolism before and know you have the prothrombin gene mutation, you may need a prescription for low-dose (preventive doses) of an injectable blood thinner (such as heparin or a low-molecular-weight heparin) during your pregnancy and for a few weeks after delivery. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. About 1 in every 50 white people in Europe and North America has the heterozygous prothrombin gene mutation, making it the second most common inherited clotting disorder. In most people, a protein called activated protein C regulates the activity of . Factor V Leiden is the most common one. When the bleeding stops, different proteins tell the clotting factors to break apart so the clot can dissipate. This site complies with the HONcode standard for trustworthy health information: verify here. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. More info. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. Deep vein thrombosis and pulmonary embolism. The mutation does not cause any symptoms in and of itself. (2019, May 20). Mayo Clinic, Rochester, Minn. June 17, 2018. The Factor V Leiden protein is harder to turn off than the normal Factor V protein. In situations where there is a greater chance of clotting (such as surgery, a leg cast, a serious illness or pregnancy) you may be treated with blood thinners until the risk has passed. Medications to treat this condition may require dietary restrictions. A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. on this website is designed to support, not to replace the relationship Do you recommend genetic testing for any of my family members? When you need health care or go to the hospital, tell your healthcare team that you have Factor V Leiden, so that they can plan the care you need. It depends on the specific details of the previous deep vein thrombosis or pulmonary embolism. Regular noncontact exercise, such as walking or swimming, is still recommended for good health. Bauer KA. Be active in ways you enjoy. Food choices are varied enough that you can have a balanced diet and not get bored of foods. Fish oils may increase a patients INR level, and as such INR levels should be checked if a patient on anticoagulants begins to take significantly higher amounts of fish oil. Cranberry juice and other cranberry products can alter the effects of anticoagulants. Deep venous thrombosis (DVT). Or maybe youve had no issues, but your loved one needed treatment for DVT. This content does not have an Arabic version. The plan depends on exercise as much as diet. Harvard T.H. 0000006722 00000 n This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. The factor V Leiden mutation itself doesnt cause any symptoms. Talk with your doctor about the risks and benefits of taking these medications. www.phac-aspc.gc.ca/pau-uap/paguide/. If you know you have the factor V gene mutation, you can work to make your body an inhospitable place for clots, starting with something under your control: your diet. Research is mixed concerning the weight loss advantage of eating smaller meals more often, but this may have other health benefits. The nutrient can interact with blood-thinning meds, but the idea is not to avoid foods high in vitamin K, like broccoli, kale, spinach and collard greens. Lockwood CJ, et al. The length of treatment may vary depending on your situation. Please use one of the following formats to cite this article in your essay, paper or report: Zoppi, Lois. There are many foods that can be beneficial to the health of patients with Factor V Leiden. She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. This is your bodys reaction to an injury that prevents you from bleeding too much. This site is not designed to and does not provide medical advice, Individuals who happen to know that they have factor V Leiden but have never had blood clots dont have to be prescribed any blood thinners. That's important because high blood pressure can damage blood vessels, increasing blood clot risk. And it provides simple recipes that promise no more than 5 ingredients and 5 minutes of prep time. Kaushansky K, et al., eds. Whole grains: Choose whole grains like whole-grain bread, quinoa, farro and brown rice rather than refined grains, such as white bread, white rice, crackers and baked goods made with white flour. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. A genetic mutation (change) causes factor V Leiden. Pruthi RK (expert opinion). These blood clots can be life-threatening. The Best Foods to Eat for Promoting Healthy Cells, Your 4-Week Mediterranean Diet Meal Plan, Curated by a Dietitian-Chef, Ready to Try the DASH Diet? The questions may keep coming, and thats normal. DVT or a PE during or shortly following pregnancy. Signs and symptoms may include: Seek medical attention immediately if you have signs or symptoms of either a DVT or a pulmonary embolism. There needs to be a balance of these proteins to make sure there is just enough clotting power: Factor V is one of the proteins needed to make blood form clots. Your brothers and sisters may have inherited the mutated gene for Factor V Leiden, just like you did. As a result, too much blood clotting can happen. But its important that these individuals discuss with their doctors what they should be aware of and what they can do to minimize the risk of DVT or PE. The clot remains in place while other enzymes repair the damaged blood vessel. Or ask someone to drive you to the nearest emergency room. advice, care, or treatment. DVT or a PE soon after starting birth control pills or hormone therapy. Wear compression stockings if your provider prescribes them for you. 0000236831 00000 n However, some people with this disorder develop DVT or PE. You may be treated with blood thinners until the risk has passed. If you have never had a blood clot, you do not need treatment with blood thinners. This field is for validation purposes and should be left unchanged. Your provider will advise you on whether you need testing, as well as on the pros and cons of testing. 3. In your body, you have 100% of Factor V Leiden and no normal Factor V. This happens in less than 1 out of 100 people. We inherit one gene from our mother and one from our father.