Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away. Yes. What conditions does Trelegy Ellipta Blister, With Inhalation Device treat. Trelegy Ellipta 100 mcg-62.5 mcg-25 mcg powder for inhalation. Consult a patients specialist providers before coadministering these immunosuppressants and ritonavir-boosted nirmatrelvir. Email this report to a friend, doctor, or patient. Bring someone with you to your appointment if doing so will help you feel more comfortable. It's not uncommon for people to take NSAIDs (e.g Ibuprofen, Advil, Aleve) with prednisone for short periods of time. [deleted] 3 mo. Also describe any vitamins, herbs, or supplements you use. Dosage of drugs is not considered in the study. Trelegy Ellipta, Advair, and Spiriva are all inhalers used to manage COPD in adults. See Is Trelegy Ellipta used for COPD? and Is Trelegy Ellipta used for asthma? below for details. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. The study uses data from the FDA. Avoid smoking and other things that can worsen breathing problems. Lauren Van Scoy, MD, is a board-certified physician in internal medicine, pulmonary medicine, and critical care. Keep all medical and lab appointments. Prednisone reduction can be accomplished by reducing the daily prednisone dose by 2.5 mg on a weekly basis during therapy with TRELEGY ELLIPTA. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This figure from a review of the topic in the European Respiratory Journal shows where in the process ICS could influence COVID-19, either increasing or decreasing risk of 1) initial infection, 2). Talk to your pharmacist for more details. It is unknown if this medication passes into breast milk. Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guide, AirDuo Digihaler (Fluticasone propionate and Salmeterol) - Inhalation, Inhaled Corticosteroids for Asthma Treatment, chronic obstructive pulmonary disease (COPD), Atrovent HFA- ipratropium bromide aerosol, metered, Incruse Ellipta- umeclidinium aerosol, powder, Spiriva Respimat- tiotropium bromide inhalation spray spray, metered, Tudorza Pressair- aclidinium bromide powder, metered, Anoro Ellipta- umeclidinium bromide and vilanterol trifenatate powder, Bevespi Aerosphere- glycopyrrolate and formoterol fumarate aerosol, metered, Breo Ellipta- fluticasone furoate and vilanterol trifenatate powder, Stiolto Respimat- tiotropium bromide and olodaterol spray, metered, Combivent Respimat- ipratropium bromide and albuterol spray, metered, Advair Diskus- fluticasone propionate and salmeterol powder, Symbicort- budesonide and formoterol fumarate dihydrate aerosol, Flovent Diskus- fluticasone propionate powder, metered, QVAR Redihaler- beclomethasone dipropionate HFA aerosol, metered, Should not be used with other medications containing antimuscarinic drugs, Bevespi Aerosphere (glycopyrrolate/formoterol), Combivent Respimat (ipratropium/albuterol), May be used with Advair or Symbicort for severe COPD, Increased risk of hypokalemia and heart rhythm problems. This product can make you more likely to get infections or may worsen any current infections. This wasnt reported in the drugs studies. Tables with guidance on managing specific drug-drug interactions: Increasing monitoring for potential adverse reactions to the concomitant medication. This is a fungal yeast infection that develops in your mouth or throat. Looking for U.S. government information and services. National Library of Medicine, DailyMed. If you are regularly taking corticosteroids by mouth (such as prednisone), continue to follow your doctor's instructions on taking them. This helps them determine whether Trelegy Ellipta is safe for you. 9 Medications You Should Never Stop Taking Abruptly - Reader's Digest Do not open the cover of the inhaler until you are ready to use it. These are sudden flare-ups of severe symptoms. Some people may have an allergic reaction to Trelegy Ellipta. What should I know about Trelegy Ellipta vs. Symbicort? Treatment Types for Severe Asthma: What to Ask Your Doctor, Everything You Need to Know About Asthma-COPD Overlap Syndrome, Where to Find Support Groups for Severe Asthma, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, COPD: How a 5-Question Screening Tool Can Help Diagnose Condition, 5 Ways to Keep Your Lungs Healthy and Strong, FEV1 and COPD: How to Interpret Your Results. This inhaler contains 3 medications: fluticasone, umeclidinium, and vilanterol. All rights reserved. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Throw away the inhaler 6 weeks after first removing it from the tray or when the dose counter reads zero, whichever comes first. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used a corticosteroid taken by mouth within the past 12 months. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Low dose prednisone can cause weight gain, increased blood pressure, worsening diabetes, osteoporosis and increase risk of heart disease. For asthma treatment, this product should be used when breathing problems are not well controlled with two asthma-control medications (such as inhaled corticosteroid and long-acting beta agonist) or if your symptoms need combination treatment. Creams and ointments can help heal many skin conditions. The dangers of leaving your medications behind in your hot car To learn more about Trelegy Ellipta and Anoro Ellipta, check out this detailed comparison. This product may contain inactive ingredients (such as milk proteins), which can cause allergic reactions or other problems. Do not use other anticholinergic drugs (such as ipratropium, tiotropium) or LABA drugs (such as formoterol, salmeterol) while using this medication. 2020. It does not work right away and should not be used to relieve sudden shortness of breath. Brian Bezack, DO, is board-certified in pediatric pulmonology and pediatrics. Please refer to the FDA EUA fact sheet for ritonavir-boosted nirmatrelvir and the prescribing information for the chemotherapeutic agent and consult the patients specialist provider. What should I know about Trelegy Ellipta vs. Anoro Ellipta? By Lauren Van Scoy, MD No, Trelegy Ellipta doesnt cause hair loss. If youre pregnant, breastfeeding, or planning either, talk with your doctor. These immunosuppressants have significant drug-drug interaction potential with ritonavir, and they should not be used if close monitoring, including therapeutic drug monitoring, is not feasible. Medication can help you manage COPD and live a long life. Stader F, Khoo S, Stoeckle M, et al. Prednisone and other corticosteroids: Balance the risks - Mayo Clinic Consult your doctor if you have been exposed to an infection or for more details. Stopping lopinavir/ritonavir in COVID-19 patients: duration of the drug interacting effect. Withhold atorvastatin and rosuvastatin at the beginning of treatment with ritonavir-boosted nirmatrelvir and resume after completion of the 5-day course. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Before you start treatment with Trelegy Ellipta, your doctor will evaluate your risk of side effects, including raised blood pressure. National Library of Medicine, DailyMed. Always consult your healthcare provider before making changes to your medications or dosage. Some mixtures of medications can lead to serious and even fatal consequences. Before you start taking Trelegy Ellipta, you and your doctor will talk and make sure the drug is a good option for you. If you have chronic obstructive pulmonary disease (COPD) or asthma, your doctor may suggest treatment with Trelegy Ellipta. What should I know about Trelegy Ellipta vs. Breztri Aerosphere? eHealthMe is studying from 531,290 Prednisone users for its effectiveness, alternative drugs and more. Albuterol (ProAir HFA, Proventil-HFA) is a common example of a rescue inhaler. No alcohol/food interactions were found. It is based on prednisone and fluticasone furoate; umeclidinium bromide; vilanterol trifenatate (the active ingredients of Prednisone and Trelegy ellipta, respectively), and Prednisone and Trelegy ellipta (the brand names). Lauren Van Scoy, MD, is a board-certified physician in internal medicine, pulmonary medicine, and critical care. This dilates (opens) your airways and makes it easier to breathe. People with COPD are commonly treated with more than one inhaler. There are a total of 30 doses per inhaler. aThis list is primarily based on the most common medication searches by U.S. users on the Liverpool COVID-19 Drug Interactions website between January 1 and July 31, 2022 (internal communication, August 2022). The recommended treatment course of ritonavir-boosted nirmatrelvir for COVID-19 is 5 days. certain antipsychotics (drugs used for mental health conditions), such as. The last thing you want to get is a cold, because it can turn into bronchitis or pneumonia. Symptoms can include: Some people experience asthma symptoms throughout the day. a Reduced effectiveness of clopidogrel is likely. Patients in the study may take other drugs besides Prednisone and Trelegy ellipta. The recommended Trelegy Ellipta dosage for COPD and asthma is one inhalation, once per day. Advil is widely available and well-known as a pain-reliever and fever-reducer. This gives the medicine time to settle in your airways and lungs. Pre-emptive dose adjustment is not required but may be considered based on an individualized assessment of the patients risk for adverse reactions. But if they become bothersome, talk with your doctor or pharmacist. Add an Answer. Methotrexate and Coronavirus: Does Methotrexate Make You - CreakyJoints They can recommend the best COPD or asthma treatment plan for you. US residents can call their local poison control center at 1-800-222-1222. The effectiveness of the drug will depend on one's biological makeup and condition. The lists below describe some of its more common side effects. Atrovent HFA- ipratropium bromide aerosol, metered [drug label]. Trelegy Ellipta is used every day to help manage symptoms. Inhaled glucocorticoids (also known as inhaled steroids) are commonly used in combination with other inhaled drugs to control COPD. Find answers to some commonly asked questions about Trelegy Ellipta. Thrush is a known side effect of a group of drugs called inhaled corticosteroids. 2023 eHealthMe.com. The use of the eHealthMe site and its content is at your own risk. Trelegy Ellipta contains three active drugs,* which are fluticasone, vilanterol, and umeclidinium. Do not share this medication with others. See the What should be considered before taking Trelegy Ellipta? below for details. Tell your doctor if your condition does not get better or if it gets worse. Raised blood pressure is a possible side effect of Trelegy Ellipta. These include what your insurance plan covers and which pharmacy you use. This report displays the potential drug interactions for the following 2 drugs: Applies to: prednisone and Trelegy Ellipta (fluticasone / umeclidinium / vilanterol). Its a possible side effect of any inhaler. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Using an alternative to the concomitant medication. Trelegy Ellipta contains a corticosteroid that you inhale, called fluticasone. One of the side effects of prednisone is bradycardia , an abnormally slowed heart rate. Certain pharmacies may provide medication labels that: Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesnt. Other medications can affect the removal of fluticasone from your body, which may affect how fluticasone works. Here are some you need to watch out for if you or someone you love is being treated for COPD: Controller medications are those used to control symptoms of COPD and prevent exacerbations. Learn about asthma complications, what to do about them, and how to decrease your risk of developing them. This can help you decide if its right for you. Prednisone is a prescription medication originally approved by the Food and Drug Administration (FDA). Key: EUA = Emergency Use Authorization; FDA = Food and Drug Administration, Clinicians should be aware that, in some cases, drug-drug interactions with ritonavir-boosted nirmatrelvir may lead to serious or life-threatening drug toxicities. Got worse but put me on prednisone,. Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, stopping smoking, limiting alcohol, and eating well-balanced meals that contain adequate calcium and vitamin D. You may also need to take calcium and vitamin D supplements. They can tell you more about your treatment options to see if one of these drugs is right for you. You can use the study as a second opinion to make health care decisions. It is used by itself or alongside other medications to treat hypertension (high blood pressure) as well as heart failure. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. In fact, using some together can pose health risks. If you develop high blood pressure while using Trelegy Ellipta, your doctor may prescribe medications to manage this. These forms help control inflammation associated with asthma and nasal allergies. Talk with your doctor if youre concerned about your weight or weight gain. Different drug combinations may work better for COPD or asthma in some people. Use your next dose at the regular time. If withholding is not clinically appropriate, use an alternative concomitant medication or COVID-19 therapy. We comply with the HONcode standard for trustworthy health information. If you have switched from a corticosteroid taken by mouth (such as prednisone tablets) to this inhaler within the past 12 months, or if you have been using this product in higher-than-usual doses for a long time, it may be more difficult for your body to respond to physical stress. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Breo Ellipta ( fluticasone furoate and vilanterol inhalation powder) and albuterol sulfate are both used to treat asthma and chronic obstructive pulmonary disease ( COPD ). If withholding a statin is not clinically appropriate (e.g., the patient had a recent myocardial infarction), the doses of atorvastatin and rosuvastatin can be adjusted and continued, and lovastatin and simvastatin should be switched to an alternative statin.g The guidance on managing drug-drug interactions between certain benzodiazepines and ritonavir-boosted nirmatrelvir can vary significantly between resources. Certain activities can also trigger asthma symptoms or make symptoms worse. How Prednisone Affects Heart Rate - Verywell Health Can You Take Aleve With Prednisone? | HelloPharmacist - Walrus Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Its a brand-name prescription drug used for COPD or asthma in adults. There are short-acting versions used as rescue inhalers and long-acting versions that are used to control COPD. ago. Check this table to make sure you can use your COPD inhalers together. Consult your doctor for details. Spiriva Respimat- tiotropium bromide inhalation spray spray, metered [drug label]. Key:AE = adverse effect; BPH = benign prostatic hyperplasia; CHA2DS2-VASc = congestive heart failure, hypertension, age, diabetes, stroke, vascular disease; CYP = cytochrome P450; EUA = Emergency Use Authorization; FDA = Food and Drug Administration; LMWH = low-molecular-weight heparin; P-gp = P-glycoprotein, Ritonavir-Boosted Nirmatrelvir (Paxlovid), Table: Characteristics of Antiviral Agents, Including Antibody Products, Table: Characteristics of Immunomodulators, Table: Characteristics of Miscellaneous Drugs, Liverpool COVID-19 Drug Interactions website, University of Waterloo/University of Toronto drug interaction guide, Therapeutic Management of Nonhospitalized Adults With COVID-19, University Health Network/Kingston Health Sciences Centre, American Society of Transplantation statement, https://www.ncbi.nlm.nih.gov/pubmed/32556272, https://www.fda.gov/media/142368/download, https://www.ncbi.nlm.nih.gov/pubmed/30843777. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Trelegy Ellipta Blister, With Inhalation Device side effects by likelihood and severity. Anoro Ellipta- umeclidinium bromide and vilanterol trifenatate powder [drug label]. But if you have severe symptoms, immediately call 911 or your local emergency number. Your doctor will explain how you should use your Trelegy Ellipta inhaler. Box 1 includes commonly prescribed medications that are not expected to have clinically relevant interactions with ritonavir-boosted nirmatrelvir. If you are using other inhalers at the same time, wait at least 1 minute between the use of each medication. Be sure to mention any prescribed or over the counter medications and other supplements you're taking. If you have an existing heart problem, raised blood pressure could make your condition worse. Hypercapnia happens when you have too much carbon dioxide in your bloodstream. This product is used to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma and ongoing lung disease ( chronic obstructive pulmonary disease - COPD, which. Advil (Ibuprofen) and Prednisone: What You Should Know - Verywell Health Call your doctor right away if you have an allergic reaction to Trelegy Ellipta. It also lists the inhalers that should not be used together as well as several that may be OK. Trelegy Ellipta contains three active drugs:* fluticasone, vilanterol, and umeclidinium. 4 How Different Categories of High Cholesterol Are Treated 4 Sources By Jennifer Moll, PharmD This medication may raise your blood pressure. National Library of Medicine, DailyMed. It works by reducing swelling of the airways in the lungs to make breathing easier. You can also check out this article to learn more about saving money on prescriptions. Bronchodilator or Steroid Inhaler: Which Should Be Used First? This side effect is caused by vilanterol, one of the three active drugs* in Trelegy Ellipta. Properly discard this product when it is expired or no longer needed. trouble breathing during physical activity, contain a code you can scan with a smartphone to change the text into audio. Always consult your healthcare provider. Antimuscarinic drugs are controller medications used once or twice daily. Drug interactions may change how your medications work or increase your risk for serious side effects. Thank you, {{form.email}}, for signing up. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you miss a dose, use it as soon as you remember. Trelegy ellipta has active ingredients of fluticasone furoate; umeclidinium bromide; vilanterol trifenatate. Trelegy Ellipta contains a corticosteroid that you inhale, called fluticasone. Topically. We study millions of patients and 5,000 more each day. This medication may temporarily slow down a child's growth if used for a long time. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. Do not stop taking them. Trelegy Ellipta (Fluticasone furoate 100 or 200 micrograms Side Effects of Trelegy Ellipta: Uses, Risks, Warnings - RxList Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If so, how often will I need to have those done? Its possible to experience an exacerbation (sudden worsening) of asthma symptoms. Your FEV1 result can be used to determine how severe your COPD is. Learn how we can help. However, the low level is not expected to be clinically significant during the 5 days of therapy. Bring these questions with. Can occur with Trelegy Ellipta: . After the last dose is administered, most of the interaction potential resolves within 2 to 3 days, although resolution may take longer in adults of advanced age.1. Trelegy Ellipta is used to improve symptoms and prevent bronchospasm in adults with COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Medication Cautions in Macular Degeneration - AMDF Ketotifen trelegy Ellipta salbutamol and multivitamin, c vitamin , d vitamin and probiotics The progestin concentration of a combined hormonal contraceptive is expected to remain similar or increase with coadministration, which would maintain the effectiveness of the oral contraceptive. Common side effects of Singulair include upper respiratory infection, fever, and sore throat. Take the inhaler from your mouth and hold your breath as long as you can up to 10 seconds. But if you think youre having a medical emergency, call 911 or your local emergency number. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. To prevent dry mouth, hoarseness, and oral yeast infections from developing, gargle, rinse your mouth with water and spit out after each use. Thrush wasnt common in studies of Trelegy Ellipta. However, combination products containing both an inhaled corticosteroid and long-acting beta agonist, such as this product, do not increase the risk of serious asthma-related breathing problems. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This is not a complete list of possible side effects. Trelegy Ellipta FDA Warnings & Precautions | Healthgrades Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. However, poorly controlled asthma can also slow down growth. Share sensitive information only on official, secure websites. Factors to consider include those in the list below. 2 Prednisone causes this by decreasing the amount of potassium, calcium, magnesium, and phosphate in the blood. But I do not think this is a black and white issue. Others are used as needed when an exacerbation occurs. Ritonavir may also increase blood concentrations of certain concomitant medications. Steroids for COPD: Benefits, Side Effects, and More - Healthline Hair loss can be caused by corticosteroids that you take by mouth, such as prednisone. Educate patients about potential adverse effects. The Trelegy Ellipta inhaler contains three active drugs: Trelegy Ellipta isnt currently available as a generic. WebMD does not provide medical advice, diagnosis or treatment. Add an Answer. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. This is not a comprehensive list of all the medications that are not expected to have clinically relevant interactions with ritonavir-boosted nirmatrelvir.a. Dosing & Delivery | TRELEGY (fluticasone furoate, umeclidinium These include brentuximab vedotin, enfortumab vedotin, polatuzumab vedotin, and tisotumab vedotin. Tudorza Pressair- aclidinium bromide powder, metered [drug label]. An official website of the United States government. Patients who are receiving higher doses of dexamethasone will be at a greater risk of AEs.k Patients should take ritonavir-boosted nirmatrelvir at least 3 hours after receipt of brincidofovir.l Ritonavir-boosted nirmatrelvir interacts with certain conjugated monoclonal antibodies, such as those conjugated to the drug monomethyl auristatin E (or vedotin). Consult the. Drug interactions are reported among people who take Prednisone and Trelegy ellipta. Codeine, morphine, and hydrocodone are opioids that doctors prescribe to treat pain. How will I know if Trelegy Ellipta is working for me. Talk with your doctor about your risk, and about available treatments for osteoporosis. Prednisone is used to treat many conditions including allergies, Crohn's disease, and chronic obstructive pulmonary disease (COPD). You may also want to discuss whether the use of a drug on this list outweighs the increased risk of side effects compared with other treatments. Trelegy Ellipta contains three active drugs:* fluticasone, vilanterol, and umeclidinium. Prednisone has active ingredients of prednisone. Trelegy Ellipta: Uses, Taking, Side Effects, Warnings - Medicine.com To improve breathing: Albuterol serves to dilate, or "open up" narrowed airways due to spasm, while the Prednisone is to relieve any narrowing that may be due to inflammation. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Because the flu virus can also worsen breathing problems, ask your doctor or pharmacist if you should have a flu shot every year. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. QVAR Redihaler- beclomethasone dipropionate HFA aerosol, metered [drug label]. If your doctor has told you to use a second capsule, follow the same steps you used for the first . 2005 - 2023 WebMD LLC. Side effects of prednisone. To lower your risk of thrush, rinse your mouth with water and spit the water out (without swallowing) after each dose of Trelegy Ellipta. Prednisone and Trelegy ellipta drug interactions, a phase IV clinical Other drugs are known to interact, causing severe drops in blood potassium and heart rhythm problems. Drug interactions are reported among people who take Prednisone and Trelegy ellipta. These include brentuximab vedotin, enfortumab vedotin, polatuzumab vedotin, and tisotumab vedotin. Combivent Respimat- ipratropium bromide and albuterol spray, metered [drug label]. Your doctor will recommend whether you should keep using Trelegy Ellipta if you have thrush. This is called bronchospasm. prednisone Trelegy Ellipta (fluticasone/umeclidinium/vilanterol) Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Some people with COPD experience exacerbations. Trelegy Ellipta: Usage, Side Effects, Warnings - Drugs.com And they want you to get the best care possible. Be Aware of These Statin Drug Interactions - Verywell Health It is often used in rheumatoid arthritis. Each time you open the cover, you prepare a dose of the medication. Note that abrupt discontinuation or rapid dose reduction of benzodiazepines may precipitate an acute withdrawal reaction.2 The risk is greatest for patients who have been using high doses of benzodiazepines over an extended period.h For patients with hepatic or renal impairment, do not coadminister this medication with ritonavir-boosted nirmatrelvir.i For medications that are not included on the Liverpool COVID-19 Drug Interactions website or the University of Waterloo/University of Toronto drug interaction guide, refer to the FDA labels for information on coadministering these medications with ritonavir or other strong CYP3A4 and/or P-gp inhibitors.j Dexamethasone exposure is expected to increase 2.60-fold when dexamethasone is coadministered with ritonavir-boosted nirmatrelvir.3 Clinicians should weigh the risks and benefits of continuing the patients normal dose of dexamethasone (while monitoring for AEs) versus decreasing the dose.
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